Recent Publications
2025
Dunipace L, McGehee JM, Irizarry J, Stathopoulos A.Genetics. The proximal enhancer of the snail gene mediates negative autoregulatory feedback in Drosophila melanogaster. Genetics. 2025 Mar 27:iyaf058. doi: 10.1093/genetics/iyaf058. Online ahead of print. PMID: 40147870
*Pimmett VL, *McGehee J, Trullo A, Douaihy M, Radulescu O, Stathopoulos A#, Lagha M#. Development. Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription. 2025 Mar 15;152(6):dev204706. doi: 10.1242/dev.204706. Epub 2025 Mar 31. PMID: 40018801
2024
*Pimmett VL, *McGehee J, Trullo A, Douaihy M, Radulescu O, Stathopoulos A#, Lagha M#.Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription. bioRxiv [Preprint]. 2024 Nov 28:2024.11.28.623729. doi: 10.1101/2024.11.28.623729.
McGehee J, Stathopoulos A. Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation. Development. 2024 Nov 1;151(21):dev202775. doi: 10.1242/dev.202775. Epub 2024 Nov 8. PMID: 39397716.
McGehee J, Stathopoulos A. Mechanisms for controlling Dorsal nuclear levels. Front Cell Dev Biol. 2024 Aug 5;12:1436369. doi: 10.3389/fcell.2024.1436369. eCollection 2024. PMID: 39161589
The people behind the papers - Jingjing Sun and Angelike Stathopoulos. Development. 2024 May 15;151(10):dev203022. doi: 10.1242/dev.203022. Epub 2024 May 17.
Sun J, Durmaz AD, Babu A, Macabenta F, Stathopoulos A. Two sequential gene expression programs bridged by cell division support long-distance collective cell migration. Development. 2024 May 15;151(10):dev202262. doi: 10.1242/dev.202262. Epub 2024 May 17. PMID: 38646822
2023
Sun J, Zhang C, Gao F, Stathopoulos A. Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm. Cell Reports. 2023: 42, 113289. 31 October, 2023.
2022
Macabenta F, Sun H-T, Stathopoulos A. BMP-gated cell-cycle progression drives anoikis during mesenchymal collective migration. Developmental Cell. 2022: 57(14): P1683-1693. Epub 15 June, 2022.
*Dunipace L, *Newcomb S, Stathopoulos A. brinker levels regulated by a promoter proximal element support germ cell homeostasis. Development. 2022: 149 (3): dev199890. Published 4 February, 2022.
2021
Ákos Z, Dunipace L, Stathopoulos A. NaNuTrap, a technique for in vivo cell nucleus labelling using nanobodies. Development. 2021 Sep 15;148(18):dev199822.
*Stevens LM, *Kim G, *Koromila T, Steele JW, McGehee J, Stathopoulos A, and Stein DS. Light-dependent N-end rule-mediated disruption of protein function in Saccharomyces cerevisiae and Drosophila melanogaster. PLoS Genetics 2021 May 17;17(5):e1009544. doi: 10.1371/journal.pgen.1009544.
Irizarry J, McGehee J, and Stathopoulos A. High levels of Dorsal transcription factor downregulate, not promote, snail expression by regulating enhancer action. BioRxiv [preprint]. Jan. 11, 2021.
Irizarry J, and Stathopoulos A. Dynamic patterning by morphogens illuminated by cis-regulatory studies. Development 2021; 148: dev196113 doi: 10.1242/dev.196113 Published 20 January 2021.
2020
Koromila T, Gao F, Iwasaki Y, He P, Pachter L, Gergen JP, and Stathopoulos A. Odd-paired is a pioneer-like factor that coordinates with Zelda to control gene expression in embryos. eLife. 2020 July 23;9:e59610.
Stepanik V, Sun J, and Stathopoulos A. FGF Pyramus Has a Transmembrane Domain and Cell-Autonomous Function in Polarity. Current Biology. 2020 August 17; 30: 1-13. Epub ahead of print 2020 July 2.
Sun J, Macabenta F, Ákos Z, and Stathopoulos A. Collective Migrations of Drosophila Embryonic Trunk and Caudal Mesoderm-Derived Muscle Precursor Cells. Genetics. 2020 June 1; vol. 215 no. 2 297-322. Flybook chapter.
*Irizarry J, *McGehee J, Kim G, Stein D, and Stathopoulos A. Twist-dependent ratchet functioning downstream from Dorsal revealed using a light-inducible degron. Genes & Development. 2020 May 28; 34: 965-972.
2019
Stathopoulos A and Newcomb S. Setting up for gastrulation: D. melanogaster. Current Topics in Developmental Biology. 2019 December 12; 136:3-32. Book chapter.
Dunipace L, Ákos Z, and Stathopoulos A. Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization. PLOS Genetics. 2019 December 12; 15(12): e1008525.
Koromila T, Gao F, Iwasaki Y, He P, Pachter L, Gergen JP, and Stathopoulos A. Odd-paired is a late-acting pioneer factor coordinating with Zelda to broadly regulate gene expression in early embryos. bioRxiv 853028; doi: https://doi.org/10.1101/853028 .
Macabenta F and Stathopoulos A. Sticking to a plan: adhesion and signaling control spatial organization of cells within migrating collectives. Curr Opin Genet Dev. 2019 August 09; 57(39-46). Review.
Koromila T and Stathopoulos A. Distinct Roles of Broadly Expressed Repressors Support Dynamic Enhancer Action and Change in Time Cell Reports. Cell Reports. 2019 July 23; 28(855-863).
Macabenta F and Stathopoulos A. Migrating cells control morphogenesis of substratum serving as track to promote directional movement of the collective. Development. 2019 July 16; 146: dev177295.
2018
Sandler J, Irizarry J, Stepanik V, Dunipace L, Amrhein H, and Stathopoulos A. A Developmental Program Truncates Long Transcripts to Temporally Regulate Cell Signaling. Dev Cell. 2018 December 17; 47(6):773-784.e6.
Sun J and Stathopoulos A.FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity. Development. 2018 October 1; 145(19).