Angela Stathopoulos
Angela Stathopoulos is currently a Professor in the Division of Biology & Biological Engineering at the California Institute of Technology located in Pasadena, California USA, where she started her laboratory 18 years ago. Throughout her career, she has studied how transcription factors and signaling pathways influence cells to regulate changes in cell shape and form during the course of development. In 1998, she obtained her Ph.D. from Stanford University in the lab of Martha Cyert studying calcium signalling and the role of the calcineurin phosphatase regulated gene expression. Subsequently, she joined the laboratory of Mike Levine at UC Berkeley for her postdoctoral training in using the Drosophila embryo as a model system to study mechanisms of transcriptional regulation. In her lab at Caltech, a systems-level approach is used to study embryonic development, in which both cis-regulatory and cell biological data are integrated with an emphasis on quantitative measures, to provide insight into the regulation of gene expression, patterning and cell migration. Recent focus has identified a new collective cell migration model system, the caudal visceral mesoderm (CVM) and use of optogenetic approaches to study the dynamic action of transcription factors. In her free time, Angela enjoys spending time with her family (mom to two college students), renovating homes with her husband John (second career choice would have been architect), travelling to new places (near water always a plus), gardening (aspiring), reading historical fiction novels, and is an animal-enthusiast, in general (with pups Stella & Luna topping the list).
Publications
- Pimmett, Virginia L;McGehee, James et al. (2024) Optogenetic manipulation of nuclear Dorsal reveals temporal requirements and consequences for transcription
- Sun, Jingjing;Durmaz, Ayse Damla et al. (2024) Two sequential gene expression programs bridged by cell division support long-distance collective cell migrationDevelopment
- Sun, Jingjing;Zhang, Chen et al. (2023) Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesodermCell Reports
- Macabenta, Frank;Sun, Hsuan-Te et al. (2022) BMP-gated cell-cycle progression drives anoikis during mesenchymal collective migrationDevelopmental Cell
- Dunipace, Leslie;Newcomb, Susan et al. (2022) Brinker levels regulated by a promoter proximal element support germ cell homeostasisDevelopment
- Ákos, Zsuzsa;Dunipace, Leslie et al. (2021) NaNuTrap: a technique for in vivo cell nucleus labelling using nanobodiesDevelopment
- Stevens, Leslie M.;Kim, Goheun et al. (2021) Light-dependent N-end rule-mediated disruption of protein function in Saccharomyces cerevisiae and Drosophila melanogasterPLOS Genetics
- Irizarry, Jihyun;McGehee, James et al. (2021) High levels of Dorsal transcription factor downregulate, not promote, snail expression by regulating enhancer action
- Irizarry, Jihyun;Stathopoulos, Angelike (2021) Dynamic patterning by morphogens illuminated by cis-regulatory studiesDevelopment
- Stepanik, Vincent;Sun, Jingjing et al. (2020) FGF Pyramus Has a Transmembrane Domain and Cell-Autonomous Function in PolarityCurrent Biology